5-AMINO-1MQ

Overview of 5-Amino-1MQ

5-Amino-1MQ, also known as 5-Amino-1-methylquinolinium, is a small molecule that has garnered significant interest within the scientific community as a potent and selective inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). NNMT is a cytosolic enzyme primarily expressed in the liver and adipose tissue, where it plays a critical role in cellular metabolism by catalyzing the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide (NAM), producing 1-methylnicotinamide (1-MNA). By blocking this pathway, 5-Amino-1MQ allows researchers to investigate the downstream effects of NNMT inhibition on metabolic flux and cellular signaling.

As a research tool, 5-Amino-1MQ is utilized to explore the relationship between NNMT activity and various physiological systems. In laboratory settings, this compound is employed to study how the modulation of the NAD+ salvage pathway affects cellular energy homeostasis. The molecular structure of 5-Amino-1MQ allows it to cross cell membranes effectively, making it a valuable asset for in-vitro assays involving adipocytes, hepatocytes, and skeletal muscle cells. Researchers utilize this compound to map the biochemical pathways involved in energy expenditure and mitochondrial function.

Chemical Structure and Identification

5-Amino-1MQ is a methylated quinolinium derivative. Its specific molecular architecture allows for high-affinity binding to the active site of NNMT, preventing the methylation of nicotinamide. Unlike many other metabolic modulators, this compound does not interact with other methyltransferases or major metabolic enzymes, ensuring that data collected during experimentation is representative of selective NNMT inhibition. In its stable form, it is typically provided as a fine powder suitable for precise weighing and reconstitution in laboratory solvents.

Specifications

Quality and precision are paramount when conducting chemical research. We provide 5-Amino-1MQ that meets the highest industry standards for analytical consistency.

• Purity: Verified at 99% or greater through stringent analytical methods.
• Testing: Each batch undergoes comprehensive third-party testing, including High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm chemical identity and purity levels.
• Documentation: A detailed Certificate of Analysis (COA) is available for every batch to ensure transparency and reproducibility in your laboratory work.
• Format: Supplied as a stable lyophilized powder to preserve chemical integrity during transport.
• Available Sizes: Currently offered in 50 mg units for precise experimental scaling.

Handling and Storage

Proper handling is essential to maintain the stability and efficacy of 5-Amino-1MQ. Upon receipt, the lyophilized powder should be stored in a controlled environment. For short-term storage, the compound is stable at room temperature; however, for long-term storage, it is recommended to keep the vial at -20°C to prevent degradation over time.

When preparing the compound for laboratory use, reconstitution is typically performed using sterile solvents such as bacteriostatic water or DMSO, depending on the requirements of the specific research protocol. Once reconstituted, the solution should be used promptly or aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles, which can compromise the molecular structure. Researchers should always utilize appropriate personal protective equipment (PPE), including gloves and safety goggles, when handling this chemical to ensure safety within the laboratory environment.

Buy 5-AMINO-1MQ Online

We provide a streamlined procurement process for institutions and independent researchers seeking high-quality 5-Amino-1MQ. Our platform is designed to facilitate the acquisition of research-grade compounds with efficiency and reliability. We understand the importance of timely delivery in the research cycle; therefore, we offer fast USA shipping on all orders to ensure your laboratory supplies arrive without unnecessary delay.

Integrity is maintained throughout the shipping process. All orders are dispatched in discreet packaging to protect the privacy and security of your materials. Our logistics network is optimized to handle sensitive chemical compounds, ensuring that your 5-Amino-1MQ arrives in optimal condition, ready for your next phase of experimentation.

Research Use Only

Compliance Notice: This product, 5-Amino-1MQ, is intended solely for laboratory research purposes. It is strictly for in-vitro use and is not a drug, food, cosmetic, or dietary supplement. This compound is not intended for human or veterinary consumption, and any administration to humans or animals is strictly prohibited. Research must be conducted by qualified professionals in a controlled laboratory setting. By purchasing this product, the buyer acknowledges the inherent risks associated with the handling of research chemicals and agrees to follow all safety guidelines. The user is responsible for ensuring that the use of this product complies with all local, state, and federal regulations.