PE-22-28

Overview of PE-22-28

PE-22-28 is a synthetic peptide fragment derived from the naturally occurring peptide known as Spadin. Spadin itself is an endogenous sortilin-derived peptide that functions as an antagonist to the TREK-1 potassium channel. TREK-1 (TWIK-related potassium channel 1) is a member of the two-pore-domain potassium (K2P) channel family, which plays a significant role in modulating cellular membrane excitability and neurotransmission within the central nervous system. PE-22-28 represents a shortened sequence of the original 17-amino acid Spadin peptide, specifically optimized for research environments focusing on ion channel modulation and neurochemistry.

In laboratory studies, PE-22-28 has been utilized to investigate the mechanisms of TREK-1 blockade. Because TREK-1 channels are highly expressed in the hippocampus and other regions associated with mood regulation and cognitive function, researchers use this peptide to map the downstream effects of potassium channel inhibition. Unlike its parent molecule, PE-22-28 is often studied for its improved stability and specific affinity within experimental models. The study of this compound is fundamental for researchers seeking to understand the biochemical pathways involved in synaptic plasticity and neuronal signaling without the confounding variables of larger, more complex protein structures.

Specifications

To ensure the integrity of experimental data, our PE-22-28 is manufactured to the highest standards of chemical synthesis. The following specifications apply to this research material:

• Purity: Greater than 99% as determined by analytical testing.
• Testing: Every batch undergoes rigorous third-party testing, including High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm identity and purity levels.
• Documentation: A Certificate of Analysis (COA) is available for every lot, providing transparency and verification for laboratory records.
• Format: Provided as a lyophilized (freeze-dried) white powder to ensure maximum stability during transit and storage.
• Available Sizes: 10 mg per vial.

Handling and Storage

Proper handling and storage are critical to maintaining the structural integrity of PE-22-28. Upon receipt, the lyophilized peptide should be stored in a controlled environment. For short-term storage (less than one month), the vial may be kept at 4°C (refrigeration). For long-term storage, it is recommended to keep the product at -20°C or -80°C to prevent degradation over time.

When preparing the peptide for laboratory use, the process of reconstitution must be performed with precision. Researchers typically use bacteriostatic water or sterile physiological saline as the diluent. During reconstitution, the liquid should be added gently to the side of the vial, followed by a slow swirling motion. Vigorous shaking or agitation should be avoided, as the mechanical stress can lead to the denaturing of the peptide bonds. Once reconstituted, the solution is significantly less stable than the lyophilized powder and should be stored at 4°C and utilized within a short timeframe, usually not exceeding 7 to 14 days, depending on the specific buffer and laboratory conditions.

Buy PE-22-28 Online

Selecting a reliable source for research chemicals is paramount for the success of scientific inquiry. We provide a streamlined procurement process for institutions and independent researchers looking to acquire high-purity PE-22-28. Our platform ensures that you receive a product that meets exact molecular specifications, supported by comprehensive analytical data.

We prioritize the efficiency and security of your order. All shipments are processed promptly to ensure fast USA shipping, minimizing the time between order placement and laboratory arrival. We utilize discreet packaging to protect the privacy of your research and ensure the contents are handled appropriately during the logistics process. By maintaining a robust supply chain, we are able to offer consistent availability of 10 mg vials for ongoing longitudinal studies.

Research Use Only

PE-22-28 is intended solely for in-vitro laboratory research purposes by qualified professionals. This product is not a drug, food, cosmetic, or dietary supplement. It is not intended for human or veterinary consumption. The chemical, physical, and toxicological properties of this compound have not been fully investigated. Any use of this product outside of a controlled research environment is strictly prohibited. By purchasing this material, the researcher acknowledges that they are trained in the handling of hazardous materials and will adhere to all safety protocols required by their institutional review board or governing regulatory body. This material is not for use in diagnostic procedures or therapeutic applications.